Joint & Bone Initiative

Dr. Tom Appleton

Assistant Professor
Physiology and Pharmacology
Health and Rehabilitation Science

(519) 646-6100

MSK Research Areas of Interest

Active Living, Animal Models, Arthritis, Clinical Outcomes, Clinical Trials, Genetics, Mobility, Molecular & Cell Biology, Musculoskeletal Imaging, Personalized Medicine, Regenerative Medicine, Rheumatology, Spine Related Pathologies

Tom Appleton joined Western in October 2016 as a Rheumatologist, practicing at the Rheumatology Centre at St. Joseph’s Hospital, and started as an Assistant Professor with Schulich in the department of Physiology and Pharmacology in January 2017. His translational biology research program in early OA, which includes multidisciplinary collaborative projects with multiple members of the BJI, is focused on investigating the mechanisms of OA disease development and progression to identify new therapeutic targets for disease modifying OA therapies. Projects include the study of a prospective, longitudinal patient cohort of patients with early OA of various phenotypes. Dr. Appleton joined the Division of Rheumatology in 2016 as a Clinician Scientist and provides clinical service to patients with inflammatory rheumatologic disorders in addition to his research. His new cross appointment in the Department of Physiology & Pharmacology facilitates the discovery aspect of his research program. Using multiple molecular biology techniques, large OA patient cohorts, and animal models of OA, he will study the molecular interplay between synovium and articular cartilage and the inflammatory mediators that drive joint damage and dysfunction in early OA.