Stephen Sims
Professor
Sims and colleagues pioneered the use of patch clamp and fluorescence methods to study authentic mammalian osteoclasts. They were the first to characterize the ion channels in osteoclasts and have since identified and characterized several classes of channel types as well as their regulation. These studies are of high impact in the bone field, with relevance to understanding the basis of diseases involving bone loss, with the osteoclast now recognized as the target for therapy in diseases such as rheumatoid arthritis, osteoporosis and metastatic tumors in bone.
